Editor’s introduction:

Issue 8 of The New Zealand Journal of Natural Medicine features an article by by Dr Rozencwagj, NMD which details the development of a new treatment for non-melanoma skin cancers. Broccoli for Non-Melanoma SkincancerNATMED 8 p63-66

This article may be downloaded as a PDF document from the link above, or read in the hard copy of issue 8 of the journal.

Below is a list of additional references to the anti-cancer activity of broccoli which are not included in PDF or printed editions of the the article.

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
Fourtounis J, Wang IM, Mathieu MC, Claveau D, Loo T, Jackson AL, Peters MA, Therien AG, Boie Y, Crackower MA.
Respir Res. 2012 Oct 12;13(1):92. [Epub ahead of print]
PMID: 23061798 [PubMed – as supplied by publisher] Free Article

Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins.
Sarkar R, Mukherjee S, Biswas J, Roy M.
Biochem Biophys Res Commun. 2012 Oct 12;427(1):80-5. doi: 10.1016/j.bbrc.2012.09.006. Epub 2012 Sep 10.
PMID: 22975350 [PubMed – in process]

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.
Park JH, Kim JW, Lee CM, Kim YD, Chung SW, Jung ID, Noh KT, Park JW, Heo DR, Shin YK, Seo JK, Park YM.
BMB Rep. 2012 May;45(5):311-6.
PMID: 22617456 [PubMed – indexed for MEDLINE] Free Article

Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P.
Int J Food Sci Nutr. 2012 Nov;63(7):767-71. doi: 10.3109/09637486.2012.665043. Epub 2012 Apr 26.
PMID: 22537070 [PubMed – in process]

Effect of phytochemicals on phase II enzyme expression in infant human primary skin fibroblast cells.
Warwick E, Cassidy A, Hanley B, Jouni ZE, Bao Y.
Br J Nutr. 2012 Mar 19:1-8. [Epub ahead of print]
PMID: 22424477 [PubMed – as supplied by publisher]

Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation.
Kim HA, Yeo Y, Jung HA, Jung YO, Park SJ, Kim SJ.
Rheumatology (Oxford). 2012 Jun;51(6):1006-16. Epub 2012 Feb 12.
PMID: 22332123 [PubMed – indexed for MEDLINE]

Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
Akhtar MJ, Ahamed M, Fareed M, Alrokayan SA, Kumar S.
J Toxicol Sci. 2012 Feb;37(1):139-48.
PMID: 22293418 [PubMed – indexed for MEDLINE] Free Article

Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer.
Hashem FA, Motawea H, El-Shabrawy AE, Shaker K, El-Sherbini S.
Phytother Res. 2012 May;26(5):743-7. doi: 10.1002/ptr.3591. Epub 2011 Nov 11.
PMID: 22076869 [PubMed – in process]

Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury.
Mao L, Wang HD, Pan H, Qiao L.
Brain Inj. 2011;25(3):300-6. Epub 2011 Jan 31.
PMID: 21280976 [PubMed – indexed for MEDLINE]

Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells.
Shan Y, Lin N, Yang X, Tan J, Zhao R, Dong S, Wang S.
Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):215-22. Epub 2010 Sep 28.
PMID: 20880684 [PubMed – indexed for MEDLINE]

Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.
Mukherjee S, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK.
Br J Nutr. 2010 Mar;103(6):815-23. Epub 2009 Oct 27.
PMID: 19857366 [PubMed – indexed for MEDLINE]

Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer.
Rushworth SA, Micheau O.
Br J Pharmacol. 2009 Aug;157(7):1186-8.
PMID: 19664138 [PubMed – indexed for MEDLINE] Free PMC Article

Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes.
Kim HA, Yeo Y, Kim WU, Kim S.
Rheumatology (Oxford). 2009 Aug;48(8):932-8. Epub 2009 Jun 2.
PMID: 19491303 [PubMed – indexed for MEDLINE] Free Article

Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.
Mukherjee S, Dey S, Bhattacharya RK, Roy M.
Mol Cell Biochem. 2009 Oct;330(1-2):9-22. Epub 2009 Apr 12.
PMID: 19363674 [PubMed – indexed for MEDLINE]

Epithiospecifier protein activity in broccoli: the link between terminal alkenyl glucosinolates and sulphoraphane nitrile.
Williams DJ, Critchley C, Pun S, Nottingham S, O’Hare TJ.
Phytochemistry. 2008 Nov;69(16):2765-73. Epub 2008 Nov 1.
PMID: 18977005 [PubMed – indexed for MEDLINE]

Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori.
Haristoy X, Fahey JW, Scholtus I, Lozniewski A.
Planta Med. 2005 Apr;71(4):326-30.
PMID: 15856408 [PubMed – indexed for MEDLINE]

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD.
Biochem J. 2003 Sep 1;374(Pt 2):337-48.
PMID: 12816537 [PubMed – indexed for MEDLINE] Free PMC Article

High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
Zhang Y, Callaway EC.
Biochem J. 2002 May 15;364(Pt 1):301-7.
PMID: 11988104 [PubMed – indexed for MEDLINE] Free PMC Article

Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
van Lieshout EM, Bedaf MM, Pieter M, Ekkel C, Nijhoff WA, Peters WH.
Carcinogenesis. 1998 Nov;19(11):2055-7.
PMID: 9855024 [PubMed – indexed for MEDLINE] Free Article

Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli.
Faulkner K, Mithen R, Williamson G.
Carcinogenesis. 1998 Apr;19(4):605-9.
PMID: 9600344 [PubMed – indexed for MEDLINE] Free Article